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When administered under labeled conditions, ReBalance is an FDA-approved, safe and effective treatment for horses with equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona. The active ingredients (sulfadiazine 250 mg/mL and pyrimethamine 12.5 mg/mL) inhibit folic acid synthesis at two different sites, in the same synthetic pathway. The combination is synergistic, with the drug combination having an anti-protozoal effect.